Compile Data Set for Download or QSAR
maximum 50k data
Found 1555 of ec50 data for polymerid = 9743
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50615023(CHEMBL5266091)
Affinity DataEC50:  0.0700nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electroc...More data for this Ligand-Target Pair
Ligand Info
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TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50615020(CHEMBL5267703)
Affinity DataEC50:  0.110nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electroc...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50354919(CHEMBL1836893)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50615022(CHEMBL5277999)
Affinity DataEC50:  0.240nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electroc...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50615021(CHEMBL5273537)
Affinity DataEC50:  0.270nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electroc...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50615019(CHEMBL5291249)
Affinity DataEC50:  0.330nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electroc...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423497(US10508115, Compound Ib-16)
Affinity DataEC50:  0.350nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423533(US10508115, Compound If-09)
Affinity DataEC50:  0.374nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50354920(CHEMBL1836892)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423515(US10508115, Compound Ie-01)
Affinity DataEC50:  0.450nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50615018(CHEMBL5272936)
Affinity DataEC50:  0.460nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electroc...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423520(US10508115, Compound Ie-06)
Affinity DataEC50:  0.460nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM393036(4-amino-2-butoxy-7-(4-(pyrrolidine-1-ylmethyl)benz...)
Affinity DataEC50:  0.5nMAssay Description:Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM393038(4-amino-2-butoxy-7-(4-((4-methylpiperazine-1-yl)me...)
Affinity DataEC50:  0.5nMAssay Description:Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM393019(2-butoxy-7-(4-(1-methylpiperidine-4-yl)benzyl)-5H-...)
Affinity DataEC50:  0.5nMAssay Description:Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM393037(4-amino-2-butoxy-7-(4-(morpholinomethyl)benzyl)-5H...)
Affinity DataEC50:  0.5nMAssay Description:Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM393035(4-amino-2-butoxy-7-((6-(pyrrolidine-1-ylmethyl)pyr...)
Affinity DataEC50:  0.5nMAssay Description:Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423493(US10508115, Compound Ib-12)
Affinity DataEC50:  0.540nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50249645(CHEMBL4078859)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of IFNalpha-mediated inhibition of HCV genotype 1b RNA replication in human HuH luc/neo ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423488(US10508115, Compound Ib-07)
Affinity DataEC50:  0.620nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423486(US10508115, Compound Ib-05)
Affinity DataEC50:  0.700nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423496(US10508115, Compound Ib-15 | US10508115, Compound ...)
Affinity DataEC50:  0.830nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423503(US10508115, Compound Ic-05)
Affinity DataEC50:  0.871nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423513(US10508115, Compound Id-07)
Affinity DataEC50:  0.890nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423487(US10508115, Compound Ib-06)
Affinity DataEC50:  0.910nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423485(US10508115, Compound Ib-04)
Affinity DataEC50:  0.910nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423510(US10508115, Compound Id-04)
Affinity DataEC50:  0.960nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM393035(4-amino-2-butoxy-7-((6-(pyrrolidine-1-ylmethyl)pyr...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50611739(CHEMBL5265854)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human TLR7 in HEK-Blue hTLR7 cells incubated for 18 hrs by quanti-blue reagent based analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50330063(1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  1nMAssay Description:Plasmacytoid dendritic cell (pDC)—enriched peripheral blood mononuclear cells (PBMCs) were prepared from the blood of a series of human donors (3-5 d...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50249646(CHEMBL4103135)
Affinity DataEC50:  1nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of IFNalpha-mediated inhibition of HCV genotype 1b RNA replication in human HuH luc/neo ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50354948(CHEMBL1836891)
Affinity DataEC50:  1nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM413447(5-(5-amino-2-methoxybenzyl)-N4-pentyl-5H-pyrrolo[3...)
Affinity DataEC50:  1nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50330063(1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  1nMAssay Description:Plasmacytoid dendritic cell (pDC)—enriched peripheral blood mononuclear cells (PBMCs) were prepared from the blood of a series of human donors (3-5 d...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM518505(N-(4-((4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1...)
Affinity DataEC50:  1nMAssay Description:Plasmacytoid dendritic cell (pDC)—enriched peripheral blood mononuclear cells (PBMCs) were prepared from the blood of a series of human donors (3-5 d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423484(US10508115, Compound Ib-03)
Affinity DataEC50:  1.10nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423496(US10508115, Compound Ib-15 | US10508115, Compound ...)
Affinity DataEC50:  1.10nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423517(US10508115, Compound Ie-03)
Affinity DataEC50:  1.12nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423509(US10508115, Compound Id-03)
Affinity DataEC50:  1.12nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423519(US10508115, Compound Ie-05)
Affinity DataEC50:  1.14nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423532(US10508115, Compound If-08)
Affinity DataEC50:  1.19nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423522(US10508115, Compound Ie-08)
Affinity DataEC50:  1.20nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423483(US10508115, Compound Ib-02)
Affinity DataEC50:  1.20nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423528(US10508115, Compound If-04)
Affinity DataEC50:  1.23nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423480(US10508115, Compound Ia-07)
Affinity DataEC50:  1.30nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423475(US10508115, Compound Ia-02)
Affinity DataEC50:  1.30nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423490(US10508115, Compound Ib-09)
Affinity DataEC50:  1.30nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423491(US10508115, Compound Ib-10)
Affinity DataEC50:  1.30nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423516(US10508115, Compound Ie-02)
Affinity DataEC50:  1.38nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM423479(US10508115, Compound Ia-06)
Affinity DataEC50:  1.40nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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